Two men were injured after a stabbing and shooting in Hackney, while two men were shot in a second shooting in Brixton and a fifth man sustained gunshot wounds in Croydon. The first incident took place in Brixton on Friday evening.
Police were called to Akerman Road just before 7pm following reports of gunshots.
Two men were left injured and rushed to a south London hospital.
A Metropolitan Police spokesman said: “Police were called at 18:52hrs on Friday, 31 July to reports of gunshots heard in the vicinity of Akerman Road, SW9.
“Officers, including firearms officers, attended and found damage to two parked vehicles. There was no trace of any victims.
“Police were called a short time later to a south London hospital after two males self-presented with gunshot injuries; we await an update on their condition.
“Officers remain at the scene. At this early stage, there have been no arrests and enquiries continue.”
Meanwhile, two men were shot after a fight broke out in Hackney. Unconfirmed reports suggest the incident took place at an unlicensed music event in the area.
Police were called to Mandeville Street in Hackney, east London, in the early hours of Saturday following reports of men fighting.
A 30-year-old and a 31-year-old man were taken to hospital with stab and gunshot injuries following the incident at 1.23am.
Both men remain in hospital.
A Met Police spokesman told Express.co.uk: “Police were called at 01:12hrs on Saturday, 1 August to Mandeville Street E5 following reports of men fighting.
“At approximately At 01:23 hrs police were informed that a 30-year-old man and a 31-year-old man had been taken to an east London hospital with stab and gunshot wounds.
“This is currently being treated as linked to the earlier incident.
“Both men are not believed to have sustained life-threatening injuries and they both remain in hospital.
“A 30-year-old man [A] and a 31-year-old man [B] have been arrested in connection with this incident and are currently custody.
A London Ambulance Service spokesman said the men made their own way to hospital.
Meanwhile, a third shooting took place in Croydon, where a man, in his 20s, was shot.
A police spokeswoman added: “Police were called at approximately 01:40hrs on Saturday, 01 August to London Road Croydon following reports of a gunshot.
“Officers, including armed officers, and London ambulance service attended.
“A man, believed to be in his twenties, was found with a gunshot wound. He has been taken to hospital and his injuries are not believed to be life threatening.
“No arrests and enquiries continue.