AMYOTROPHIC lateral sclerosis (ALS) is a motor neurone disease (MND) which is a neurological disorder that affects voluntary muscles in the body.
It slowly causes the death of neurons in these muscles, leading to stiffness, twitching, weakness and eventually leads to difficulties speaking, swallowing and breathing.
Getty – Contributor Prof Stephen Hawking passed away on March 14
While there have been several high-profile sufferers in the 20th century, the disease became well-known in 2014 when an online challenge went viral.
The ‘ice bucket challenge’, also known as the ‘ALS ice bucket challenge’, saw participants tip buckets of freezing water full of ice over themselves or others, after being nominated.
Once someone completed the challenge, they then nominated three friends to follow suit.
Many celebrities took part in the challenge, helping to boost its popularity, including Oprah, Bill Gates, Christ Pratt, Lady GaGa, Taylor Swift and Justin Bieber.
PA:Press Association Stephen Hawking when given two years to live when diagnosed aged 21
Professor Stephen Hawking, who passed away on March 14, also starred in an ALS ice bucket challenge in 2014, when he introduced his three children undertaking the challenge on his behalf, as he had recently had pneumonia.
He said: “I urge everyone to donate to the MNDA [Motor Neurone Disease Association] to eliminate this terrible disease.”
By 2015 it was estimated to have raised more than £82 million pounds for research into ALS.
What is ALS life expectancy?
ALS is usually diagnosed around 60 and in inherited cases from age 50 onwards.
There is no known cause, although in around five to ten per cent of cases it is hereditary.
Getty – Contributor ALS causes muscles to deteriorate over time
From diagnosis, ALS sufferers usually have a life expectancy of two to four years.
Around ten per cent of people live longer than a decade after diagnosis, and the most common cause of death among those with ALS is respiratory failure.
Why is it called Lou Gehrig’s disease?
ALS is also known as MND, Charcot disease and Lou Gehrig’s disease.
Henry Louis “Lou” Gehrig was born in the US in 1903, and was a successful baseball player.
He held many records in his day, including the most career grand slams, 23, broken in 2013, and the most consecutive games played, 2,130 which stood for 56 years.
Corbis In North America ALS is commonly referred to as Lou Gehrig’s disease
Nicknamed ‘The Iron Horse’, he had a stellar career but his performance nosedived, and he was diagnosed with ALS on his 36th birthday in June 1939.
Two days after his diagnosis, he retired from the sport and his condition was made public.
Just two years later, on June 2 1941, Lou Gehrig passed away.
Due to his fame, ALS is commonly referred to as Lou Gehrig’s disease in North America.
What causes Stephen Hawking’s MND?
Professor Stephen Hawking was diagnosed with a rare, early onset and slow-progressing from of ALS in 1963, aged 21.
At the time he was given a life expectancy of two years, but continued for another half a century, defying the odds.
The disease causes the atrophy – degeneration – of muscles throughout the body.
Meghan And Harry’s Official Wedding China Has Gone On Sale… And We Want To Buy The Lot
PRINCE Harry and Meghan Markle’s wedding is approaching next month with the cake and dress designer all rumoured to be in place.
The pair are due to wed next month at Windsor Castle, and as part of celebrations marking the occasion an official line of commemorative china has gone on sale.
Royal Collection Trust Meghan is an American actress
Personally approved by the couple, the range was unveiled by The Royal Collection Trust and is available to buy on their website.
There are just five pieces in the collection, a miniature mug costing £19.95, a full size mug costing £25, a £35 pillbox, a tankard for £29 and a plate which costs £49.
The border design is inspired by the 13th century Gilebertus door of St George’s Chapel, where the ceremony will be held.
The bone china is finished in cornflower blue with white detailing, and bears the couple’s initials in gold, tied with a white ribbon.
Royal Collection Trust All profits from the china will go to charity
Royal Collection Trust The plate is the most expensive item
Finished in 22 carat gold, each piece will be presented in a blue gift box and accompanied by a miniature card explaining the design and detailing the couple’s upcoming wedding.
Nuala McGourty, Royal Collection Trust’s retail director, said: “Royal Collection Trust is delighted to offer the official range of commemorative china to celebrate this happy occasion.
Royal Collection Trust It is believed the pair will be made the Duke and Duchess of Sussex
Royal Collection Trust The couple personally approved the design
“We are pleased to continue our support of the potteries of Stoke-on-Trent, who have manufactured our previous commemorative wares to celebrate royal birthdays, anniversaries and weddings.”
The china was hand-made in Stoke-on-Trent using traditional methods, and all profits from sales will go to registered charity The Royal Collection Trust.
The collection can also be purchased from Royal Collection Trust shops at The Queen’s Gallery, Buckingham Palace, Windsor Castle and the Palace of Holyroodhouse.
Royal Collection Trust Meghan’s real name is in fact Rachel
Can You Tell The Difference Between These £18 Heels And An £830 Gianvito Rossi Pair?
EVERYBODY wears shoes, from work boots to high heels or flip flops and slippers around the house.
A well-made pair of designer shoes can cost thousands with some labels, such as Gianvito Rossi, seeming out of reach without applying for a loan.
The shoe on the left is the pricey designer heel
But without shelling out an eye-watering amount, you can rock a nearly identical pair of the label’s stiletto ankle sock boots, which cost £830 including tax.
Online retailer EGO sells a dupe pair for £17.49, down from £34.99.
In classic black, they’re guaranteed to go with nearly every outfit.
But with one costing hundreds less than the other, you’ll have some cash left over to buy a whole new wardrobe to pair them with.
The bottom shoe is the Gucci number
And with summer on the way if something breathable is more your style, you may fancy a pair of Gucci’s Princetown metallic leather slippers.
But with a £535 price tag, if you’re willing to compromise these pair from online shop WithChic are a bargain at £26.72, down from £31.36, and even feature the same gold chain detail.
Rolo Pointed Toe Sock Boot In Black Faux Suede, £17.49, EGO
This heel is currently on sale, saving you even more money Metal Detail Glitter Overlay Flat Mules, £26.72, WithChic
This glittery number stands out from the crowd
We Test Sultry Nightwear To Set Pulses Racing As You Ditch Your Winter Warmers
THE clocks go forward this weekend – so it’s time to swap your winter-warmer nightwear for sexier numbers. Put away those flannel PJs and bulky dressing gowns and set pulses racing with sultry spring-summer sets.
Here, CLEMMIE FIELDSEND gets model Tinna Bergs, 33, from Putney, South West London, to try some of the best and give each a verdict and rating out of five.
Tinna says: ‘Top feels unique and bust detail is sexy’ Top, £35, figleaves.com Pants, £25, M&S SUN RATING: 4.5/5
Tinna says: ‘Bra is sweet, comfy for bed, but big shorts are unsexy’ Pink with white embroidery set, £10, Boohoo.com SUN RATING: 2.5/5
Tinna says: ‘A nice print but the one-piece is restrictive in bed’ Floral teddy, £15, Prettylittlething.com SUN RATING: 2/5
Tinna says: ‘Comfy but still feminine with the lace. Not the sexiest – but practical’ Top, £16, Debenhams Brief, £10, Debenhams SUN RATING: 3.5/5
Tinna says: ‘The pale shade is nice and subtle, and lace keeps it sexy.’ Green set, £16, F&F SUN RATING: 4.5/5
Tinna says: ‘It’s my favourite. I love the plunge top and the shorts’ frills. Comfy but sexy’ Navy top and shorts, £10, Boohoo.com SUN RATING: 5/5
Wide bordered tulle, £100 per metre, macculloch-wallis.co.uk Spice Girl Mel B dances in her underwear in adorable Instagram video GOT a story? RING The Sun on 0207 782 4104 or WHATSAPP on 07423720250 or EMAIL email@example.com
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